Sensitization of trigeminal nociception specific for migraine but not pain of sinusitis

被引:64
作者
Katsarava, Z
Lehnerdt, G
Duda, B
Ellrich, J
Diener, HC
Kaube, H
机构
[1] Univ Essen Gesamthsch, Dept Neurol, D-45122 Essen, Germany
[2] Univ Essen Gesamthsch, Dept Otorhinolaryngol, D-45122 Essen, Germany
[3] Univ Erlangen Nurnberg, Dept Expt & Clin Pharmacol & Toxicol, D-8520 Erlangen, Germany
[4] UCL Natl Hosp Neurol & Neurosurg, Inst Neurol, London WC1N 3BG, England
关键词
D O I
10.1212/WNL.59.9.1450
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Trigeminal pain processing was studied in 14 patients with unilateral migraine attacks and 14 age- and sex-matched patients with comparable unilateral headache from frontal sinusitis. Using a nociception-specific blink reflex method (nBR), a facilitation of nBR responses predominantly on the headache side was observed in migraine, but not in sinusitis. The facilitation of trigeminal nociception may be specific for migraine rather than a consequence of peripheral pain such as frontal sinusitis.
引用
收藏
页码:1450 / 1453
页数:4
相关论文
共 11 条
[1]
Brainstem activation specific to migraine headache [J].
Bahra, A ;
Matharu, MS ;
Buchel, C ;
Frackowiak, RSJ ;
Goadsby, PJ .
LANCET, 2001, 357 (9261) :1016-1017
[2]
Burstein R, 2000, ANN NEUROL, V47, P614, DOI 10.1002/1531-8249(200005)47:5<614::AID-ANA9>3.3.CO
[3]
2-E
[4]
Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons [J].
Burstein, R ;
Yamamura, H ;
Malick, A ;
Strassman, AM .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 79 (02) :964-982
[5]
A new method to increase nociception specificity of the human blink reflex [J].
Kaube, H ;
Katsarava, Z ;
Käufer, T ;
Diener, HC ;
Ellrich, J .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (03) :413-416
[6]
Acute migraine headache - Possible sensitization of neurons in the spinal trigeminal nucleus? [J].
Kaube, H ;
Katsarava, Z ;
Przywara, S ;
Drepper, J ;
Ellrich, J ;
Diener, HC .
NEUROLOGY, 2002, 58 (08) :1234-1238
[7]
The periaqueductal grey matter modulates trigeminovascular input: A role in migraine? [J].
Knight, YE ;
Goadsby, PJ .
NEUROSCIENCE, 2001, 106 (04) :793-800
[8]
Experimental cranial pain elicited by capsaicin:: a PET study [J].
May, A ;
Kaube, H ;
Büchel, C ;
Eichten, C ;
Rijntjes, M ;
Jüptner, M ;
Weiller, C ;
Diener, HC .
PAIN, 1998, 74 (01) :61-66
[9]
Delayed inflammation in rat meninges: implications for migraine pathophysiology [J].
Reuter, U ;
Bolay, H ;
Jansen-Olesen, I ;
Chiarugi, A ;
del Rio, MS ;
Letourneau, R ;
Theoharides, TC ;
Waeber, C ;
Moskowitz, MA .
BRAIN, 2001, 124 :2490-2502
[10]
SILBERSTEIN S, 2001, WOLFFS HEADACHE, P494