Insulin-like growth factor (IGF)-I, IGF-binding protein-3 and colorectal adenomas in Japanese men

被引:25
作者
Teramukai, S
Rohan, T
Lee, KY
Eguchi, H
Oda, T
Kono, S
机构
[1] Kyushu Univ, Fac Med Sci, Dept Prevent Med, Higashi Ku, Fukuoka 8128582, Japan
[2] Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10461 USA
[3] Self Def Forces Fukuoka Hosp, Kasuga, Fukuoka 8160826, Japan
[4] Self Def Forces Kumamoto Hosp, Kumamoto 8620902, Japan
来源
JAPANESE JOURNAL OF CANCER RESEARCH | 2002年 / 93卷 / 11期
关键词
IGF-I; IGFBP-3; obesity; plasma glucose; colorectal adenomas;
D O I
10.1111/j.1349-7006.2002.tb01222.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Several epidemiological studies have found that high levels of plasma insulin-like growth factor (IGF)-I and low levels of IGF-binding protein (IGFBP)-3 are related to an increased risk of colorectal cancer or late-stage adenomas. We examined the relation of body mass index, fasting and 2-h postload plasma glucose levels and plasma concentrations of IGF-I and IGFBP-3 to colorectal adenomas in middle-aged Japanese men. The study subjects comprised 157 cases of histologically diagnosed colorectal adenomas and 311 controls with normal colonoscopy or non-polyp benign lesions in a consecutive series of 803 men receiving a preretirement health examination at two hospitals of the Self Defense Forces (SDF). After adjustment for rank in the SDF, hospital, smoking and IGFBP-3, a statistically nonsignificant modest increase in the prevalence odds of colorectal adenomas was observed for the highest versus the lowest quartile level of IGF-I. The increase was slightly greater with further adjustment for 2-h glucose concentrations (adjusted odds ratio 1.8, 95% confidence interval 1.0-4.5, trend P=0.06). Men with high levels of IGFBP-3 showed only a minimal decrease in risk after adjustment for IGF-I. The association with IGF-I was less evident for advanced adenomas (greater than or equal to5 mm in size or tubulovillous/villous). Fasting and 2-h glucose and body mass index were more strongly positively associated with colorectal adenomas than IGF-I, especially with advanced adenomas, independently of IGF-I and IGFBP-3. The findings suggest that plasma IGF-I and IGFBP-3 may be involved in colorectal tumorigenesis regardless of the stage in growth of adenoma, but not as a mediator for the effects of being overweight or of hyperglycemia.
引用
收藏
页码:1187 / 1194
页数:8
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