Genomic scale profiling of autoimmune inflammation in the central nervous system: the nervous response to inflammation

被引:62
作者
Carmody, RJ
Hilliard, B
Maguschak, K
Chodosh, LA
Chen, YH [1 ]
机构
[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Dept Med, Philadelphia, PA 19104 USA
关键词
brain; EAE/MS; autoimmunity; microarray; genomics;
D O I
10.1016/S0165-5728(02)00366-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Using gene microarray technology, we found that inflammation in the central nervous system (CNS) not only induced the expression of many immune-related genes, but also significantly altered the gene expression profile of neural cells. Two unique groups of CNS genes were identified. The first group includes genes encoding ion channels, neural transmitters and growth factors. The second group includes genes that are important for nervous tissue regeneration. Additionally, a distinct pattern of gene expression was also identified in recovering animals. Thus, during autoimmune inflammation, the CNS actively responds to immune attacks by activating its own defense and repair genes. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:95 / 107
页数:13
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