An eye's view of T regulatory cells

被引:30
作者
Stein-Streilein, Joan
Taylor, Andrew W.
机构
[1] Schepens Eye Res Inst, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA
关键词
immune regulation; TGF-beta; ACAID;
D O I
10.1189/jlb.0606383
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
T regulatory (Treg) cells have been studied for more than 30 years. Recently, changing technology and attitudes have led to new interest in T cell regulation of the immune responses. The eye is an immune-privileged site with unique mechanisms for the prevention of damaging immune inflammation. The eye fashions its Treg cells in novel ways to prevent immune inflammation locally and systemically. The purpose of this mini-review is to condense and summarize reports of Treg cells dependent on the eye in the context of the Treg literature in general.
引用
收藏
页码:593 / 598
页数:6
相关论文
共 101 条
  • [1] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Barrat, FJ
    Cua, DJ
    Boonstra, A
    Richards, DF
    Crain, C
    Savelkoul, HF
    de Waal-Malefyt, R
    Coffman, RL
    Hawrylowicz, CM
    O'Garra, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) : 603 - 616
  • [2] BORA NS, 1993, INVEST OPHTH VIS SCI, V34, P3579
  • [3] IMMUNOREGULATORY CIRCUITS AMONG T-CELL SETS - IDENTIFICATION OF A SUB-POPULATION OF T-HELPER CELLS THAT INDUCES FEEDBACK INHIBITION
    CANTOR, H
    HUGENBERGER, J
    MCVAYBOUDREAU, L
    EARDLEY, DD
    KEMP, J
    SHEN, FW
    GERSHON, RK
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 148 (04) : 871 - 877
  • [4] Cassis L, 2005, CONTRIB NEPHROL, V146, P121, DOI 10.1159/000082072
  • [5] Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    Chen, WJ
    Jin, WW
    Hardegen, N
    Lei, KJ
    Li, L
    Marinos, N
    McGrady, G
    Wahl, SM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) : 1875 - 1886
  • [6] TGF-β:: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression
    Chen, WJ
    Wahl, SM
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2003, 14 (02) : 85 - 89
  • [7] Resurrecting CD8+ suppressor T cells
    Chess, L
    Jiang, H
    [J]. NATURE IMMUNOLOGY, 2004, 5 (05) : 469 - 471
  • [8] alpha-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation
    Chiao, H
    Foster, S
    Thomas, R
    Lipton, J
    Star, RA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (09) : 2038 - 2044
  • [9] Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ re latory thyrnocytes
    Cosmi, L
    Liotta, F
    Lazzeri, E
    Francalanci, M
    Angeli, R
    Mazzinghi, B
    Santarlasci, V
    Manetti, R
    Vanini, V
    Romagnani, P
    Maggi, E
    Romagnani, S
    Annunziato, F
    [J]. BLOOD, 2003, 102 (12) : 4107 - 4114
  • [10] IMMUNE PRIVILEGE AND SUPPRESSION OF IMMUNOGENIC INFLAMMATION IN THE ANTERIOR-CHAMBER OF THE EYE
    COUSINS, SW
    TRATTLER, WB
    STREILEIN, JW
    [J]. CURRENT EYE RESEARCH, 1991, 10 (04) : 287 - 297