Determination of Phthalates in Diet and Bedding for Experimental Animals Using Gas Chromatography-Mass Spectrometry

被引：10

作者：

Kondo, Fumio ^{[1
,2
]}

Okumura, Masanao ^{[2
]}

Oka, Hisao ^{[2
]}

Nakazawa, Hiroyuki ^{[3
]}

Izumi, Shun-ichiro ^{[4
]}

Makino, Tsunehisa ^{[4
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Pharmacol, Aichi 4801195, Japan

[2] Aichi Prefectural Inst Publ Hlth, Dept Toxicol, Kita Ku, Nagoya, Aichi 4628576, Japan

[3] Hoshi Univ, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan

[4] Tokai Univ, Sch Med, Dept Obstet & Gynecol, Isehara, Kanagawa 251193, Japan

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2010年 / 84卷 / 02期

关键词：

Phthalates; Animal diets; Beddings; Gas chromatography-mass spectrometry; ORAL TOXICITY; RAT; DI(2-ETHYLHEXYL)PHTHALATE; METABOLITES; POPULATION; EXPOSURE;

D O I：

10.1007/s00128-009-9919-x

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We have developed a gas chromatography-mass spectrometry method to measure five phthalates (dibutyl phthalate, butylbenzyl phthalate, di-2-ethylhexyl phthalate, diisooctyl phthalate, and diisononyl phthalate) in diets and beddings for experimental animals. The recoveries from diets and beddings spiked with five phthalates were 98.8%-148% with coefficients of variation of 0.4%-7.8% for diets and 94.7%-146% with coefficients of variation of 1.0%-5.0% for beddings. We analyzed commercial animal diets and beddings, and found that the levels of phthalates varied from sample to sample; the concentrations of five phthalates were 141-1,410 ng/g for diets and 20.5-7,560 ng/g for beddings.

引用

页码：212 / 216

页数：5

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