Multiple Mechanisms for Hydrogen Peroxide-Induced Apoptosis

被引：26

作者：

Cerella, Claudia ^{[1
]}

Coppola, Simona ^{[1
]}

Maresca, Vittoria ^{[1
]}

De Nicola, Milena ^{[1
]}

Radogna, Flavia ^{[1
]}

Ghibelli, Lina ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

来源：

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS | 2009年 / 1171卷

关键词：

hydrogen peroxide; apoptosis; ADP-ribosylation; ADP-RIBOSYLATION; OXIDANT INJURY; H2O2-INDUCED APOPTOSIS; P388D1; CELLS; POLYMERASE; INHIBITORS; GLYCOLYSIS; PATHWAYS; INCREASE; ADENINE;

D O I：

10.1111/j.1749-6632.2009.04901.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H2O2-induced mitochondrial alterations.

引用

页码：559 / 563

页数：5

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