Do intranasal corticosteroids affect childhood growth?

被引:11
作者
Allen, DB [1 ]
机构
[1] Univ Wisconsin, Childrens Hosp, Madison, WI 53792 USA
关键词
D O I
10.1034/j.1398-9995.2000.00704.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Topical intranasal corticosteroids (INS) are the most effective treatment for allergic rhinitis and are being increasingly prescribed to children. Due to the potent inhibition of childhood growth seen with oral corticosteroids, it is important to examine whether INS could have similar effects. The evidence available suggests that some INS, such as beclomethasone dipropionate (BDP), may slow growth when used regularly for prolonged periods. However, newer INS such as fluticasone propionate (FP) and mometasone furoate, which have substantially reduced bioavailability via gastrointestinal absorption, are unlikely to do so. Well-designed prospective studies are needed to distinguish those INS with reduced or absent effects on growth. In practice, choosing an INS which optimises the ratio of therapeutic effect to systemic bioavailability will probably reduce the risk of growth suppression to a negligible level.
引用
收藏
页码:15 / 18
页数:4
相关论文
共 15 条
[1]   Growth in asthmatic children treated with fluticasone propionate [J].
Allen, DB ;
Bronsky, EA ;
LaForce, CF ;
Nathan, RA ;
Tinkelman, DG ;
Vandewalker, ML ;
Konig, P .
JOURNAL OF PEDIATRICS, 1998, 132 (03) :472-477
[2]   Influence of inhaled corticosteroids on growth: a pediatric endocrinologist's perspective [J].
Allen, DB .
ACTA PAEDIATRICA, 1998, 87 (02) :123-129
[3]  
ALLEN DB, 1996, GROWTH GROWTH DISORD, P699
[4]  
Daley-Yates Peter T., 1998, Allergy (Copenhagen), V53, P158
[5]   PREDICTIVE VALUE OF SHORT-TERM GROWTH USING KNEMOMETRY IN A LARGE POPULATION OF HEALTHY-CHILDREN [J].
DEAN, HJ ;
SCHENTAG, CT ;
WINTER, JSD .
ACTA PAEDIATRICA SCANDINAVICA, 1990, 79 (01) :57-63
[6]  
FIOCCHI A, 1999, EUR RESPIR J, V14, pS13
[7]   Establishing a therapeutic index for the inhaled corticosteroids: Part I. Pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids [J].
Kelly, HW .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (04) :S36-S51
[8]   THE EFFECT ON GROWTH OF CHILDHOOD ASTHMA [J].
MARTIN, AJ ;
LANDAU, LI ;
PHELAN, PD .
ACTA PAEDIATRICA SCANDINAVICA, 1981, 70 (05) :683-688
[9]  
MOLLER C, 1994, ALLERGY CLIN IMMU S2, V6, P427
[10]  
Rachelefsky GS, 1998, J ALLERGY CLIN IMMUN, V101, pS236