Anti-hyperlipidemic Sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.):: Structure requirement and mode of action

被引：116

作者：

Shimoda, H

Ninomiya, K

Nishida, N

Yoshino, T

Morikawa, T

Matsuda, H

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Morishita Jintan Co Ltd, Div Res & Dev, Chuo Ku, Osaka 5408566, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(02)00889-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract from the leaves of artichoke (Cynara scolymus L.) was found to suppress serum triglyceride elevation in olive oil-loaded mice. Through bioassay-guided separation, sesquiterpenes (cynaropicrin, aguerin B, and grosheimin) were isolated as the active components together with new sesquiterpene glycosides (cynarascolosides A, B, and C). The oxygen functional groups at the 3- and 8-positions and exo-methylene moiety in alpha-methylene-gamma-butyrolactone ring were found to be essential for the anti-hyperlipidemic activity of guaiane-type sesquiterpene. In addition, inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：223 / 228

页数：6

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