Objective: We aimed to investigate whether there is any seasonal variation in risk of anemia among pregnant Nepali women. Methods: We studied the hematocrit values in pregnant women (n = 5495) attending Patan Hospital, Kathmandu for the first antenatal visit in the 2-year period from January 1994 until December 1995. In a sub-sample of subjects (n = 2706), additional information was obtained through interviews and clinical examinations. Logistic regression models were used to analyze data. Results: Mean hematocrit values recorded in the monsoon period were significantly lower than hematocrit values recorded in the winter. The prevalence of moderate (hematocrit 25-33%) and severe (hematocrit < 25%) anemia was highest in September. Conclusions: We found a clear seasonal variation in risk of anemia, which was associated with rainfall and temperature. The monsoon seems to be a period when interventions may give the most beneficial effects. (C) 2000 International Federation of Gynecology and Obstetrics.