Highly enantioselective phenylacetylene additions to both aliphatic and aromatic aldehydes

被引：190

作者：

Gao, G

Moore, D

Xie, RG

Pu, L

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

[2] Sichuan Univ, Dept Chem, Chengdu, Peoples R China

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 23期

关键词：

D O I：

10.1021/ol026921r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The readily available and inexpensive BINOL in combination with Ti((OPr)-Pr-i)(4) is found to catalyze the reaction of an alkynylzinc reagent with various types of aldehydes including aliphatic aldehydes, aromatic aldehydes, and other alpha,beta-unsaturated aldehydes to generate chiral propargyl alcohols with 91-99% ee at room temperature. No previous chiral catalysts have exhibited such a broad scope of enantioselectivity with respect to the type of aldehydes for this reaction.

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页码：4143 / 4146

页数：4

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