Breast cancer: Aromatase inhibitors take on tamoxifen

被引：27

作者：

Dowsett, M

Howell, A

机构：

[1] Royal Marsden NHS Trust, Acad Dept Biochem, London, England

[2] Univ Manchester, Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester, Lancs, England

来源：

NATURE MEDICINE | 2002年 / 8卷 / 12期

关键词：

D O I：

10.1038/nm1202-1341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is the most common malignancy in females in most western countries, with about 1 in 10 women at risk of developing the disease in the course of their lifetimes. Since its introduction over 30 years ago, tamoxifen has been the mainstay of the endocrine treatment of breast cancer. It has become the most widely used anticancer drug, and may be thought of as among the first targeted therapies. Yet the results of a major new trial of endocrine therapy after surgery for breast cancer using aromatase inhibitors cast into question tamoxifen's future role.

引用

页码：1341 / 1344

页数：4

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