学术探索
学术期刊
新闻热点
数据分析
智能评审

Synthesis of constrained bicyclic dipeptide mimetics

被引：15
作者：
Siddiqui, MA
Preville, P
Tarazi, M
Warder, SE
Eby, P
Gorseth, E
Puumala, K
DiMaio, J
机构：
[1] BioChem Therapeutic Inc., Lavai, Que., H7V 4A7
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期
关键词：
D O I：
10.1016/S0040-4039(97)10422-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of constrained bicyclic peptidomimetics of (R)-Phe-Pro dipeptide is described, Such mimetics may provide an opportunity to develop inhibitors of thrombin possessing the desired pharmacological features. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：8807 / 8810
页数：4
相关论文
共 17 条
  • [1] SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
    BALDWIN, JE
    HULME, C
    EDWARDS, AJ
    SCHOFIELD, CJ
    PARKES, KEB
    [J]. TETRAHEDRON LETTERS, 1993, 34 (10) : 1665 - 1668
  • [2] BETA-TURN TOPOGRAPHY
    BALL, JB
    HUGHES, RA
    ALEWOOD, PF
    ANDREWS, PR
    [J]. TETRAHEDRON, 1993, 49 (17) : 3467 - 3478
  • [3] BROWN HC, 1980, SYNTHESIS-STUTTGART, P151
  • [4] CONFORMATIONALLY CONSTRAINED DIPEPTIDES - SYNTHESIS OF 7,5-FUSED AND 6,5-FUSED BICYCLIC LACTAMS BY STEREOSELECTIVE RADICAL CYCLIZATIONS
    COLOMBO, L
    DIGIACOMO, M
    SCOLASTICO, C
    MANZONI, L
    BELVISI, L
    MOLTENI, V
    [J]. TETRAHEDRON LETTERS, 1995, 36 (04) : 625 - 628
  • [5] Thrombin and factor Xa inhibition
    Edmunds, JJ
    Rapundalo, ST
    Siddiqui, MA
    [J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 31, 1996, 31 : 51 - 60
  • [6] ASYMMETRIC ALKYLATION REACTIONS OF CHIRAL IMIDE ENOLATES - A PRACTICAL APPROACH TO THE ENANTIOSELECTIVE SYNTHESIS OF ALPHA-SUBSTITUTED CARBOXYLIC-ACID DERIVATIVES
    EVANS, DA
    ENNIS, MD
    MATHRE, DJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (06) : 1737 - 1739
  • [7] BIOACTIVE CONFORMATION OF LUTEINIZING-HORMONE-RELEASING HORMONE - EVIDENCE FROM A CONFORMATIONALLY CONSTRAINED ANALOG
    FREIDINGER, RM
    VEBER, DF
    PERLOW, DS
    BROOKS, JR
    SAPERSTEIN, R
    [J]. SCIENCE, 1980, 210 (4470) : 656 - 658
  • [8] HARKER LA, 1994, HEMOSTASIS THROMBOSI, P1638
  • [9] KAHN M, 1993, SYNLETT, P821
  • [10] NONPEPTIDE MIMETICS OF BETA-TURNS - A FACILE OXIDATIVE INTRAMOLECULAR CYCLO-ADDITION OF AN AZODICARBONYL SYSTEM
    KAHN, M
    WILKE, S
    CHEN, B
    FUJITA, K
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (05) : 1638 - 1639
12