Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

被引：27

作者：

Uvyn, Annemiek ^{[1
]}

De Coen, Ruben ^{[1
]}

De Wever, Olivier ^{[2
]}

Deswarte, Kim ^{[3
,4
]}

Lambrecht, Bart N. ^{[3
,4
]}

De Geest, Bruno G. ^{[1
]}

机构：

[1] Univ Ghent, Dept Pharmaceut, Ghent, Belgium

[2] Univ Ghent, Dept Human Struct & Repair, Ghent, Belgium

[3] VIB Ctr Inflammat Res, Lab Mucosal Immunol & Immunoregulat, Ghent, Belgium

[4] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 73期

基金：

欧洲研究理事会;

关键词：

MOLECULES; INNATE;

D O I：

10.1039/c9cc03379c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.

引用

收藏

页码：10952 / 10955

页数：4

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