G/A(1947) polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease

被引：56

作者：

Xie, T

Ho, SL

Li, LSW

Ma, OCK

机构：

[1] UNIV HONG KONG,QUEEN MARY HOSP,DEPT MED,DIV NEUROL,HONG KONG,HONG KONG

[2] UNIV HONG KONG,QUEEN MARY HOSP,CLIN BIOCHEM UNIT,HONG KONG,HONG KONG

来源：

MOVEMENT DISORDERS | 1997年 / 12卷 / 03期

关键词：

Parkinson's disease; catechol-O-methyltransferase; polymorphism;

D O I：

10.1002/mds.870120325

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine(10S) polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.

引用

页码：426 / 427

页数：2

共 7 条

[1] HUMAN CATECHOL-O-METHYLTRANSFERASE - CLONING AND EXPRESSION OF THE MEMBRANE-ASSOCIATED FORM [J].