Effects of short-term estrogen treatment on the neointimal response to balloon injury of rat carotid artery

被引：54

作者：

Mori, T

Durand, J

Chen, YF

Thompson, JA

Bakir, S

Oparil, S

机构：

[1] Univ Alabama, Vasc Biol & Hypertens Program, Div Cardiovasc Dis, Dept Med, Birmingham, AL USA

[2] Univ Alabama, Div Transplantat, Dept Surg, Birmingham, AL USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 85卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(00)00748-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study tested the hypothesis that estrogen inhibits the response to balloon injury of the rat carotid artery by modulating molecular events occuring early (72 hours) in the postinjury period. Short-term estrogen treatment beginning on the day of injury and continuing for 3 days reduced neointima formation by 60%, indicating that estrogen protects injured blood vessels by perturbing cellular and/or molecular events occurring early in the injury response.

引用

收藏

页码：1276 / +

页数：5

相关论文

共 12 条

[1] INHIBITORY EFFECTS OF ANTISENSE OLIGODEOXYNUCLEOTIDES TARGETING C-MYC MESSENGER-RNA ON SMOOTH-MUSCLE CELL-PROLIFERATION AND MIGRATION [J].

BIRO, S ;

FU, YM ;

YU, ZX ;

EPSTEIN, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :654-658

[2] Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery [J].

Chen, SJ ;

Li, HB ;

Durand, J ;

Oparil, S ;

Chen, YF .

CIRCULATION, 1996, 93 (03) :577-584

[3]

CLOWES AW, 1983, LAB INVEST, V49, P208

[4] Medroxyprogesterone attenuates estrogen-mediated inhibition of neointima formation after balloon injury of the rat carotid artery [J].

Levine, RL ;

Chen, SJ ;

Durand, J ;

Chen, YF ;

Oparil, S .

CIRCULATION, 1996, 94 (09) :2221-2227

[5] Estrogen inhibits vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro [J].

Li, GH ;

Chen, YF ;

Greene, GL ;

Oparil, S ;

Thompson, JA .

CIRCULATION, 1999, 100 (15) :1639-1645

[6] PROLIFERATION OF SMOOTH-MUSCLE CELLS AFTER VASCULAR INJURY IS INHIBITED BY AN ANTIBODY AGAINST BASIC FIBROBLAST GROWTH-FACTOR [J].

LINDNER, V ;

REIDY, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3739-3743

[7] INTIMAL HYPERPLASIA AFTER VASCULAR INJURY IS INHIBITED BY ANTISENSE CDK-2 KINASE OLIGONUCLEOTIDES [J].

MORISHITA, R ;

GIBBONS, GH ;

ELLISON, KE ;

NAKAJIMA, M ;

VONDERLEYEN, H ;

ZHANG, LN ;

KANEDA, Y ;

OGIHARA, T ;

DZAU, VJ .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04) :1458-1464

[8] Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries [J].

Oparil, S ;

Chen, SJ ;

Chen, YF ;

Durand, JN ;

Allen, L ;

Thompson, JA .

CARDIOVASCULAR RESEARCH, 1999, 44 (03) :608-614

[9] Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries [J].

Scott, NA ;

Cipolla, GD ;

Ross, CE ;

Dunn, B ;

Martin, FH ;

Simonet, L ;

Wilcox, JN .

CIRCULATION, 1996, 93 (12) :2178-2187

[10] TRANSCATHETER DELIVERY OF C-MYC ANTISENSE OLIGOMERS REDUCES NEOINTIMAL FORMATION IN A PORCINE MODEL OF CORONARY-ARTERY BALLOON INJURY [J].

SHI, Y ;

FARD, A ;

GALEO, A ;

HUTCHINSON, HG ;

VERMANI, P ;

DODGE, GR ;

HALL, DJ ;

SHAHEEN, F ;

ZALEWSKI, A .

CIRCULATION, 1994, 90 (02) :944-951