Spectrofluorimetric determination of methyl paraben in pharmaceutical preparations by means of its dansyl chloride derivative

被引：14

作者：

Cruces-Blanco, C ^{[1
]}

Carretero, AS ^{[1
]}

Peinado, SF ^{[1
]}

Gutiérrez, AF ^{[1
]}

机构：

[1] Univ Granada, Fac Sci, Dept Analyt Chem, E-18071 Granada, Spain

来源：

MIKROCHIMICA ACTA | 2000年 / 134卷 / 1-2期

关键词：

methyl paraben; dansyl chloride; fluorimetric determination; pharmaceutical preparations;

D O I：

10.1007/s006040070062

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A spectrofluorimetric method for the determination of methyl paraben based on derivatization with the labelling reagent dansyl chloride (DNS-Cl), is presented. The effect of the reaction variables (pH, DNS-Cl concentration, temperature, reaction time) and instrumental parameters, has been examined. A linear calibration graph in the ng/ml range has been established. The limit of detection is 18 ng/ml with relative standard deviation less than 3%. The proposed method has been satisfactorily applied to determination of the paraben in two pharmaceutical preparations.

引用

页码：107 / 111

页数：5

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