The role of microbes in Crohn's disease

被引:152
作者
Eckburg, Paul B.
Relman, David A.
机构
[1] Stanford Univ, Div Infect Dis & Geog Med, Sch Med, Dept Med, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA
[3] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA
关键词
D O I
10.1086/510385
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite decades of research, the etiology of Crohn's disease ( CD) remains unknown. Its pathogenesis may involve a complex interplay between host genetics, immune dysfunction, and microbial or environmental factors. Microorganisms, including pathogens and members of the indigenous microbiota, may initiate or propagate the inflammatory process in CD. The pathogenesis of CD has been difficult to study, owing to the broad spectrum of typically nonspecific clinical manifestations, the complexity of environmental and genetic factors, the lack of an accurate model of disease, and the limitations of microbiological methods. A more useful and relevant paradigm for the etiology of CD might be based on the idea of a pathogenic microbial community profile and might emphasize the role of interactive sets of microbes, rather than the role of individual organisms. We review how microbes may participate in the pathogenesis of CD and how they may inappropriately activate the mucosal immune system in genetically predisposed individuals.
引用
收藏
页码:256 / 262
页数:7
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