Display technologies: Application for the discovery of drug and gene delivery agents

被引:192
作者
Sergeeva, Anna
Kolonin, Mikhail G.
Molldrem, Jeffrey J.
Pasqualini, Renata
Arap, Wadih
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA
[3] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
关键词
combinatorial peptide libraries; vascular cell surface proteomics; targetomics; targeted therapies; display scaffold; phage display; viral display; bacterial display; yeast display; cell display; ribosome display; mRNA display; covalent DNA display;
D O I
10.1016/j.addr.2006.09.018
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recognition of molecular diversity of cell surface proteornes in disease is essential for the development of targeted therapies. Progress in targeted therapeutics requires establishing effective approaches for high-throughput identification of agents specific for clinically relevant cell surface markers. Over the past decade, a number of platform strategies have been developed to screen polypeptide libraries for ligands targeting receptors selectively expressed in the context of various cell surface proteomes. Streamlined procedures for identification of ligand-receptor pairs that could serve as targets in disease diagnosis, profiling, imaging and therapy have relied on the display technologies, in which polypeptides with desired binding profiles can be serially selected, in a process called biopanning, based on their physical linkage with the encoding nucleic acid. These technologies include virus/phage display, cell display, ribosomal display, mRNA display and covalent DNA display (CDT), with phage display being by far the most utilized. The scope of this review is the recent advancements in the display technologies with a particular emphasis on molecular mapping of cell surface proteomes with peptide phage display. Prospective applications of targeted compounds derived from display libraries in the discovery of targeted drugs and gene therapy vectors are discussed. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:1622 / 1654
页数:33
相关论文
共 325 条
[1]   Rapid selection of specific MAP kinase-binders from designed ankyrin repeat protein libraries [J].
Amstutz, P ;
Koch, H ;
Binz, HK ;
Deuber, SA ;
Plückthun, A .
PROTEIN ENGINEERING DESIGN & SELECTION, 2006, 19 (05) :219-229
[2]   A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells [J].
Andersen, PS ;
Stryhn, A ;
Hansen, BE ;
Fugger, L ;
Engberg, J ;
Buus, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :1820-1824
[3]   Toward optimized antibody microarrays:: a comparison of current microarray support materials [J].
Angenendt, P ;
Glökler, J ;
Murphy, D ;
Lehrach, H ;
Cahill, DJ .
ANALYTICAL BIOCHEMISTRY, 2002, 309 (02) :253-260
[4]   Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands [J].
Arap, MA ;
Lahdenranta, J ;
Mintz, PJ ;
Hajitou, A ;
Sarkis, AS ;
Arap, W ;
Pasqualini, R .
CANCER CELL, 2004, 6 (03) :275-284
[5]   Model of unidirectional transluminal gene transfer [J].
Arap, MA ;
Lahdenranta, J ;
Hajitou, A ;
Marini, FC ;
Wood, CG ;
Wright, KC ;
Fueyo, J ;
Arap, W ;
Pasqualini, R .
MOLECULAR THERAPY, 2004, 9 (02) :305-310
[6]   Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].
Arap, W ;
Pasqualini, R ;
Ruoslahti, E .
SCIENCE, 1998, 279 (5349) :377-380
[7]   Steps toward mapping the human vasculature by phage display [J].
Arap, W ;
Kolonin, MG ;
Trepel, M ;
Lahdenranta, J ;
Cardó-Vila, M ;
Giordano, RJ ;
Mintz, PJ ;
Ardelt, PU ;
Yao, VJ ;
Vidal, CI ;
Chen, L ;
Flamm, A ;
Valtanen, H ;
Weavind, LM ;
Hicks, ME ;
Pollock, RE ;
Botz, GH ;
Bucana, CD ;
Koivunen, E ;
Cahill, D ;
Troncoso, P ;
Baggerly, KA ;
Pentz, RD ;
Do, KA ;
Logothetis, CJ ;
Pasqualini, R .
NATURE MEDICINE, 2002, 8 (02) :121-127
[8]   Targeting the prostate for destruction through a vascular address [J].
Arap, W ;
Haedicke, W ;
Bernasconi, M ;
Kain, R ;
Rajotte, D ;
Krajewski, S ;
Ellerby, HM ;
Bredesen, DE ;
Pasqualini, R ;
Ruoslahti, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1527-1531
[9]   Targeting urothelium: Ex vivo assay standardization and selection of internalizing ligands [J].
Ardelt, PU ;
Wood, CG ;
Chen, L ;
Mintz, PJ ;
Moya, C ;
Arap, MA ;
Wright, KC ;
Pasqualini, R ;
Arap, W .
JOURNAL OF UROLOGY, 2003, 169 (04) :1535-1540
[10]   Differential gene expression in human abdominal aorta: Aneurysmal versus occlusive disease [J].
Armstrong, PJ ;
Johanning, JM ;
Calton, WC ;
Delatore, JR ;
Franklin, DP ;
Han, DC ;
Carey, DJ ;
Elmore, JR .
JOURNAL OF VASCULAR SURGERY, 2002, 35 (02) :346-355