Synthesis and phosphatase inhibitory activity of analogs of sulfircin

被引：48

作者：

Cebula, RE ^{[1
]}

Blanchard, JL ^{[1
]}

Boisclair, MD ^{[1
]}

Pal, K ^{[1
]}

Bockovich, NJ ^{[1
]}

机构：

[1] MITOTIX INC,CAMBRIDGE,MA 02139

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(97)00357-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of sulfircin (1) were synthesized and tested for inhibitory activity against a panel of phosphatases. We attempted to optimize the potency and selectivity of sulfircin for Cdc25A by modifying three structural areas of the molecule. An anionic group is required for potency and malonate was found to be an effective substitute for sulfate. (C) 1997 Elsevier Science Ltd.

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页码：2015 / 2020

页数：6

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