A facile method for the synthesis of 6-aryl-1-(3-chloropropanoyl)-4-[(E)-1-(2-furyl)methylidene)]-1,2,3,4,-tetrahydro-3-pyridazinones and 2-(2-chloroethyl)-5-[α-aracyl-β-(2-furyl)]-(E)-vinyl-1,3,4-oxadiazoles

被引：27

作者：

Hamad, ASS ^{[1
]}

Hashem, AI ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt

来源：

MOLECULES | 2000年 / 5卷 / 06期

关键词：

2(3H)-furanone; 3-oxopyridazines; dihydropyridazines; 1,3,4-oxadiazoles;

D O I：

10.3390/50600895

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The 6-aryl-1-(3-chloropropanoyl)-4-[(E)-1-(2-furyl)methylidene)]-1,2,3,4-tetra-hydro-3-pyridazinones (6a-d) were synthesized by the reaction of acid chloride 3 with alpha-aracyl(beta-2-furyl)acrylic acid hydrazides (2a-d) in a high yield, one pot reaction. On the other hand, 2-(2-chloroethyl)-5-[alpha-aracyl-beta-(2-furyl)]-(E)-vinyl-1,3,4-oxadiazoles (7a-d) were also prepared by cyclodehydration of N-1[alpha-aracyl-beta(2-furyl)acroyl-N-2[3-chloro-propanoyl] hydrazine derivatives (4a-d). The proposed structures of the products were confirmed by elemental analysis, spectral data and chemical evidence.

引用

页码：895 / 907

页数：13

共 23 条

[1]

STRUCTURE OF AMINES BY NUCLEAR MAGNETIC RESONANCE SPECTROMETRY [J].

ANDERSON, WR ;

SILVERST.RM .

ANALYTICAL CHEMISTRY, 1965, 37 (11) :1417-&

[2]

AWAD WI, 1967, J CHEM U A R, V10, P287

[3]

AWAD WI, 1975, INDIAN J CHEM, V13, P1139

[4]

BINDER, 1987, Patent No. 19173233

[5]

CAJOCORIUS J, 1977, REW CHIM, V28, P15

[6]

6-PHENYL-4,5-DIHYDRO-3(H-2)-PYRIDAZINONES - SERIES OF HYPOTENSIVE AGENTS [J].

CURRAN, WV ;

ROSS, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) :273-281

[7]

El-Kafrawy A. F., 1993, Egyptian Journal of Pharmaceutical Sciences, V34, P159

[8]

ELKOUSY SM, 1988, PHARMAZIE, V43, P80

[9]

FERRES H, 1982, DRUGS EXP CLIN RES, V52, P964

[10]

SYNTHESIS OF ENOL LACTONES OF (E)-3-AROYL-2-(5-METHYL-2-FURYLMETHYLENE AND 5-METHYL-2-THIENYLMETHYLENE)PROPIONIC ACIDS AND THEIR CONVERSION INTO THE CORRESPONDING 4-ARYLBENZOL[B](2-METHYL-FURAN AND 2-METHYLTHIOPHENE)-S-CARBOXYLIC ACIDS [J].

GUIRGUIS, NR ;

AWAD, BM ;

SAAD, HA .

JOURNAL FUR PRAKTISCHE CHEMIE, 1990, 332 (03) :414-418

← 1 2 3 →