T cells versus HIV-1:: fighting exhaustion as well as escape

被引：6

作者：

Robinson, HL ^{[1
]}

机构：

[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30329 USA

[2] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1038/ni0103-12

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A study in a recent issue of Nature showing the lack of cross-protective immunity in an infected patient to a closely related strain of HIV-1 suggests that vaccine strategy may need to be re-examined.

引用

页码：12 / 13

页数：2

共 12 条

[1] HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus [J].

Altfeld, M ;

Allen, TM ;

Yu, XG ;

Johnston, MN ;

Agrawal, D ;

Korber, BT ;

Montefiori, DC ;

O'Connor, DH ;

Davis, BT ;

Lee, PK ;

Maier, EL ;

Harlow, J ;

Goulder, PJR ;

Brander, C ;

Rosenberg, ES ;

Walker, BD .

NATURE, 2002, 420 (6914) :434-439

[2] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes [J].

Barouch, DH ;

Kunstman, J ;

Kuroda, MJ ;

Schmitz, JE ;

Santra, S ;

Peyerl, FW ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Gorgone, DA ;

Montefiori, DC ;

Lewis, MG ;

Wolinsky, SM ;

Letvin, NL .

NATURE, 2002, 415 (6869) :335-339

[3]

KAECH SM, IN PRESS CELL

[4]

KORBER BT, 2000, HIV MOL IMMUNOLOGY 2

[5] Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS [J].

Kostense, S ;

Vandenberghe, K ;

Joling, J ;

Van Baarle, D ;

Nanlohy, N ;

Manting, E ;

Miedema, F .

BLOOD, 2002, 99 (07) :2505-2511

[6]

KUIKEN C, 2001, HIV SEQUENCE COMPEND

[7] Prognosis in HIV-1 infection predicted by the quantity of virus in plasma [J].

Mellors, JW ;

Rinaldo, CR ;

Gupta, P ;

White, RM ;

Todd, JA ;

Kingsley, LA .

SCIENCE, 1996, 272 (5265) :1167-1170

[8]

Migueles SA, 2002, NAT IMMUNOL, V3, P1061, DOI 10.1038/ni845

[9] Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection [J].

O'Connor, DH ;

Allen, TM ;

Vogel, TU ;

Jing, PC ;

DeSouza, IP ;

Dodds, E ;

Dunphy, EJ ;

Melsaether, C ;

Mothé, B ;

Yamamoto, H ;

Horton, H ;

Wilson, N ;

Hughes, AL ;

Watkins, DI .

NATURE MEDICINE, 2002, 8 (05) :493-499

[10] New hope for an AIDS vaccine [J].

Robinson, HL .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (04) :239-250

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