Intestinal flora in very low-birth weight infants

被引:44
作者
Bjorkstrom, Markus V. [1 ]
Hall, Lina [2 ]
Soderlund, Stina [1 ]
Hakansson, Eva Grahn [3 ,4 ]
Hakansson, Stellan [1 ]
Domellof, Magnus [1 ]
机构
[1] Umea Univ, Dept Clin Sci, Umea, Sweden
[2] Umea Univ, Dept Biomed Sci, Umea, Sweden
[3] Umea Univ, Dept Clin Bacteriol, Umea, Sweden
[4] Essum AB, Umea, Sweden
关键词
Feacal calprotectin; Infant; Intestinal flora; Necrotizing enterocolitis; Very low-birth weight; NEONATAL NECROTIZING ENTEROCOLITIS; BACTERIAL-COLONIZATION; MICROFLORA; PROBIOTICS; MICROBIOTA; ECOSYSTEM; GUT;
D O I
10.1111/j.1651-2227.2009.01471.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aim: To study the early faecal microbiota in very low-birth weight infants (VLBW, < 1500 g), possible associations between faecal microbiota and faecal calprotectin (f-calprotectin) and to describe the faecal microbiota in cases with necrotizing enterocolitis (NEC) before diagnosis. Methods: Stool samples from the first weeks of life were analysed in 48 VLBW infants. Bacterial cultures were performed and f-calprotectin concentrations were measured. In three NEC cases, cultures were performed on stool samples obtained before diagnosis. Results: Bifidobacteria and lactobacilli were often identified in the first stool sample, 55% and 71% of cases, respectively within the first week of life. A positive correlation between lactic acid bacteria (LAB) and volume of enteral feed was found. Other bacteria often identified were Escherichia coli, Enterococcus and Staphyloccus sp. F-calprotectin was not associated with any bacterial species. All NEC cases had an early colonization of LAB. Prior to onset of disease, all cases had a high colonization of non-E. coli Gram-negative species. Conclusion: In contrast to the previous studies in VLBW infants, we found an early colonization with LAB. We speculate that this may be due to early feeding of non-pasteurized breast milk.
引用
收藏
页码:1762 / 1767
页数:6
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