Diallyl sulfide inhibits murine WEHI-3 leukemia cells in BALB/c mice in vitro and in vivo

被引：20

作者：

Yu, Fu-Shun ^{[2
]}

Wu, Chih-Chung ^{[3
]}

Chen, Chi-Tsai ^{[4
]}

Huang, Shang-Pang ^{[5
]}

Yang, Jai-Sing ^{[6
]}

Hsu, Yuan-Man ^{[1
]}

Wu, Ping-Ping ^{[7
,8
]}

Ip, Siu-Wan ^{[9
]}

Lin, Jing-Pin ^{[10
]}

Lin, Jaung-Geng ^{[5
]}

Chung, Jing-Gung ^{[1
]}

机构：

[1] China Med Univ, Dept Biol Sci & Technol, Taichung 40402, Taiwan

[2] China Med Univ, Sch Dent Hyg, Taichung 40402, Taiwan

[3] Chang Jung Christian Univ, Dept Hlth Sci, Tainan, Taiwan

[4] Chung Haw Univ Med Technol, Dept Food Nutr, Tainan, Taiwan

[5] China Med Univ, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan

[6] China Med Univ, Dept Pharmacol, Taichung 40402, Taiwan

[7] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan

[8] China Med Univ, Sch Pharm, Taichung 40402, Taiwan

[9] China Med Univ, Dept Nutr, Taichung 40402, Taiwan

[10] China Med Univ, Sch Chinese Med, Taichung 40402, Taiwan

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2009年 / 28卷 / 12期

关键词：

Diallyl sulfide; WEHI-3; cells; leukemia murine model; in vivo; SWISS ALBINO MICE; MYELOMONOCYTIC LEUKEMIA; RETINOIC ACID; SKIN TUMORS; DIFFERENTIATION; INDUCTION; MODULATION; APOPTOSIS;

D O I：

10.1177/0960327109350670

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

It is well documented that enhanced garlic (Allium sativum) consumption leads to decrease in the cancer incidences. Diallyl sulfide (DAS), one of the components of garlic, induces cytotoxicity and apoptosis in many cancer cell lines. The present studies are focused on the in vivo effects of DAS on leukemia WEHI-3 cells in the BALB/c mice. We examined the effects of DAS on the cytotoxicity of WEHI-3 cells and results indicated that DAS decreased the percentage of viable WEHI-3 cells and these effects are dose-dependent. We examined the effects of DAS on WEHI-3 in vivo and the results indicated that DAS decreased the percentage of Mac-3 and CD11b, indicating that the differentiation of the precursor of macrophage cells was inhibited. DAS stimulated the percentage of CD3 and CD19, indicating that the differentiation of the precursor of T and B cells promoted. The weights of liver and spleen indicated that DAS decreased the weight of these organs after being compared to the control groups. One of the major characteristic of WEHI-3 leukemia is the enlarged spleen in murine after intraperitoneal (i.p.) injection of WEHI-3 cells. In conclusion, DAS affects WEHI-3 cells both in vitro and in vivo.

引用

页码：785 / 790

页数：6

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