The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

被引：494

作者：

Daniels, Tracy R.

Delgado, Tracie

Rodriguez, Jose A.

Helguera, Gustavo

Penichet, Manuel L.

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Div Surg Oncol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

来源：

CLINICAL IMMUNOLOGY | 2006年 / 121卷 / 02期

关键词：

transferrin receptor; iron; receptor-mediated endocytosis; monoclonal antibodies; recombinant antibodies; immunotherapy; cancer;

D O I：

10.1016/j.clim.2006.06.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and in the regulation of cell growth. Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR. In addition, the TfR may also contain other growth regulatory properties in certain normal and malignant cells. The elevated levels of TfR in malignancies, its relevance in cancer, and the extracellular accessibility of this molecule make it an excellent antigen for the treatment of cancer using antibodies. The TfR can be targeted by monoclonal antibodies specific for the extracellular domain of the receptor. In this review, we summarize advancements in the basic physiology of the TfR including structure, function, and expression. We also discuss the efficacy of targeting the TfR using cytotoxic antibodies that inhibit cell growth and/or induce apoptosis in targeted malignant cells. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：144 / 158

页数：15

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