The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI

被引：57

作者：

Bussey, H

Storms, RK

Ahmed, A

Albermann, K

Allen, E

Ansorge, W

Araujo, R

Aparicio, A

Barrell, B

Badcock, K

Benes, V

Botstein, D

Bowman, S

Bruckner, M

Carpenter, J

Cherry, JM

Chung, E

Churcher, C

Coster, F

Davis, K

Davis, RW

Dietrich, FS

Delius, H

DiPaolo, T

Dubois, E

Dusterhoft, A

Duncan, M

Floeth, M

Fortin, N

Friesen, JD

Fritz, C

Goffeau, A

Hall, J

Hebling, U

Heumann, K

Hilbert, H

Hillier, L

HunickeSmith, S

Hyman, R

Johnston, M

Kalman, S

Kleine, K

Komp, C

Kurdi, O

Lashkari, D

Lew, H

Lin, A

Lin, D

Louis, EJ

Marathe, R

机构：

[1] CONCORDIA UNIV,DEPT BIOL,MONTREAL,PQ H3G 1M8,CANADA

[2] HOSP SICK CHILDREN,RES INST,TORONTO,ON M5G 1X8,CANADA

[3] MAX PLANCK INST BIOCHEM,MARTINSRIEDER INST PROT SEQUENZEN,D-82152 MARTINSRIED,GERMANY

[4] STANFORD UNIV,DEPT BIOCHEM,STANFORD,CA 94305

[5] EUROPEAN MOL BIOL LAB,PROT DESIGN GRP,D-69117 HEIDELBERG,GERMANY

[6] SANGER CTR,CAMBRIDGE CB10 1SA,ENGLAND

[7] GENOTYPE GMBH,D-69259 WILHELMSFELD,GERMANY

[8] UNIV CATHOLIQUE LOUVAIN,UNITE BIOCHIM PHYSIOL,B-1348 LOUVAIN,BELGIUM

[9] DEUTSCH KREBSFORSCHUNGSZENTRUM,D-69120 HEIDELBERG,GERMANY

[10] CERIA COOVI,RES INST,B-1070 BRUSSELS,BELGIUM

[11] FREE UNIV BRUSSELS,MICROBIOL LAB,B-1050 BRUSSELS,BELGIUM

[12] QIAGEN GMBH,D-40724 HILDEN,GERMANY

[13] WASHINGTON UNIV,SCH MED,GENOME SEQUENCING CTR,ST LOUIS,MO 63110

[14] JOHN RADCLIFFE HOSP,INST MOL MED,OXFORD OX3 9DU,ENGLAND

[15] GESELL ANAL TECH & CONSULTING MBH,D-78467 CONSTANCE,GERMANY

[16] GESELL MOL BIOL TECHNOL MBH,AGON,D-12489 BERLIN,GERMANY

[17] VLAAMS INSTERUNIV INST BIOTHECHNOL,DEPT MICROBIOL,B-1070 BRUSSELS,BELGIUM

[18] FREE UNIV BRUSSELS,LAB ERFELIJKHEIDSLEER & MICROBIOL,BRUSSELS,BELGIUM

[19] FREE UNIV BRUSSELS,LAB PHYSIOL CELLULAIRE & GENET LEVURES,B-1050 BRUSSELS,BELGIUM

来源：

NATURE | 1997年 / 387卷 / 6632期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/387s103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nucleotide sequence of the 948,061 base pairs of chromosome XVI has been determined, completing the sequence of the yeast genome. Chromosome XVI was the last yeast chromosome identified(1), and some of the genes mapped early to it, such as GAL4, PEP4 and RAD1 (ref. 2) have played important roles in the development of yeast biology. The architecture of this final chromosome seems to be typical of the large yeast chromosomes, and shows large duplications with other yeast chromosomes. Chromosome XVI contains 487 potential protein-encoding genes, 17 tRNA genes and two small nuclear RNA genes; 27% of the genes have significant similarities to human gene products, and 48% are new and of unknown biological function. Systematic efforts to explore gene function have begun.

引用

页码：103 / 105

页数：3

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