Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

被引：116

作者：

Rios, Ramon ^{[1
]}

Sunden, Henrik ^{[1
]}

Ibrahem, Ismail ^{[1
]}

Zhao, Gui-Ling ^{[1
]}

Eriksson, Lars ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 48期

关键词：

D O I：

10.1016/j.tetlet.2006.09.135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantio selective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and alpha,beta-unsaturated aldehydes proceed with excellent chemoand enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98% ee. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8547 / 8551

页数：5

共 47 条

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