Viral disease transmitted by laser-generated plume (Aerosol)

被引:158
作者
Garden, JM
O'Banion, K
Bakus, AD
Olson, C
机构
[1] Northwestern Univ, Dept Dermatol, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Biomed Engn, Chicago, IL 60611 USA
[3] Childrens Mem Hosp, Div Dermatol & Plast Surg, Chicago, IL 60614 USA
[4] Univ Rochester, Dept Med, Rochester, NY USA
[5] Univ Wisconsin, Dept Vet Sci, Madison, WI 53706 USA
关键词
D O I
10.1001/archderm.138.10.1303
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective: To evaluate the possibility of disease transmission through liberated plume from virally infected tissue that is exposed to the carbon dioxide laser. Design: Bovine papillomavirus-induced cutaneous fibropapillomas were exposed to the carbon dioxide laser. Laser settings were within the range of clinically used settings. The laser plume (aerosol) was suctioned and collected and then reinoculated onto the skin of calves. Setting: University laboratory research center. Main Outcome Measures: Laser plume viral content and postinoculation tumor growth were analyzed and documented. Results: Collected laser plume contained papillomavirus DNA in all tested laser settings. The viral DNA was most likely encapsulated. Tumors developed at laser plume-inoculated sites for all laser parameter settings. Histological and biochemical analyses revealed that these tumors were infected with the same virus type as present in the laser plume. Conclusions: Laser plume has been shown, for the first time to our knowledge, to actually transmit disease. Strict care must be maintained by the laser practitioner to minimize potential health risks, especially when treating viral-induced lesions or patients with viral disease.
引用
收藏
页码:1303 / 1307
页数:5
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