Sympatholysis after neuron-specific, N-type, voltage-sensitive calcium channel blockade: First demonstration of N-channel function in humans

被引：50

作者：

McGuire, D

Bowersox, S

Fellmann, JD

Luther, RR

机构：

[1] UNIV CALIF SAN FRANCISCO,MED CTR,DEPT NEUROL,SAN FRANCISCO,CA 94143

[2] NEUREX CORP,MENLO PK,CA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1997年 / 30卷 / 03期

关键词：

SNX-111; calcium channel blocker;

D O I：

10.1097/00005344-199709000-00019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SNX-111 is the first neuronal N-type, voltage-sensitive calcium channel (VSCC) blocker to enter clinical drug development. Areas of potential therapeutic utility include treatment of nociceptive and neuropathic pain and neuroprotection after ischemic brain injury. The data presented demonstrate that SNX-111 is biologically active in humans and indicate for the first time a neurophysiologic function of N-type VSCCs in humans.

引用

收藏

页码：400 / 403

页数：4

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