Thoughts for food: Brain mechanisms and peripheral energy balance

被引:85
作者
Abizaid, Alfonso
Gao, Qian
Horvath, Tamas L.
机构
[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA
[3] Yale Univ, Sch Med, Comparat Med Sect, New Haven, CT 06520 USA
关键词
D O I
10.1016/j.neuron.2006.08.025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The past decade has witnessed dramatic advancements regarding the neuroendocrine control of food intake and energy homeostasis and the effects of peripheral metabolic signals on the brain. The development of molecular and genetic tools to visualize and selectively manipulate components of homeostatic systems, in combination with well-established neuroanatomical, electrophysiological, behavioral, and pharmacological techniques, are beginning to provide a clearer picture of the intricate circuits and mechanisms of these complex processes. In this review, we attempt to provide some highlights of these advancements and pinpoint some of the shortcomings of the current understanding of the brain's involvement in the regulation of daily energy homeostasis. © 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:691 / 702
页数:12
相关论文
共 173 条
[1]   Clock gene expressions in the suprachiasmatic nucleus and other areas of the brain during rhythm splitting in CS mice [J].
Abe, H ;
Honma, S ;
Namihira, M ;
Masubuchi, S ;
Ikeda, M ;
Ebihara, S ;
Honma, K .
MOLECULAR BRAIN RESEARCH, 2001, 87 (01) :92-99
[2]  
ABIZAID A, 2006, IN PRESS J CLIN INVE
[3]  
ADAN RAH, 1994, MOL PHARMACOL, V46, P1182
[4]   Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons [J].
Alon, T ;
Friedman, JM .
JOURNAL OF NEUROSCIENCE, 2006, 26 (02) :389-397
[5]  
ANAND BK, 1951, P SOC EXP BIOL MED, V77, P323, DOI 10.3181/00379727-77-18766
[6]   Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy [J].
Bagnasco, M ;
Dube, MG ;
Kalra, PS ;
Kalra, SP .
ENDOCRINOLOGY, 2002, 143 (11) :4409-4421
[7]  
Bailey ART, 2000, J NEUROENDOCRINOL, V12, P191
[8]   Divergence of melanocortin pathways in the control of food intake and energy expenditure [J].
Balthasar, N ;
Dalgaard, LT ;
Lee, CE ;
Yu, J ;
Funahashi, H ;
Williams, T ;
Ferreira, M ;
Tang, V ;
McGovern, RA ;
Kenny, CD ;
Christiansen, LM ;
Edelstein, E ;
Choi, B ;
Boss, O ;
Aschkenasi, C ;
Zhang, CY ;
Mountjoy, K ;
Kishi, T ;
Elmquist, JK ;
Lowell, BB .
CELL, 2005, 123 (03) :493-505
[9]   Leptin receptor signaling in is required for normal body POW neurons weight homeostasis [J].
Balthasar, N ;
Coppari, R ;
McMinn, J ;
Liu, SM ;
Lee, CE ;
Tang, V ;
Kenny, CD ;
McGovern, RA ;
Chua, SC ;
Elmquist, JK ;
Lowell, BB .
NEURON, 2004, 42 (06) :983-991
[10]   Leptin sensitive neurons in the hypothalamus [J].
Baskin, DG ;
Hahn, TM ;
Schwartz, MW .
HORMONE AND METABOLIC RESEARCH, 1999, 31 (05) :345-350