Synthesis of the monomeric building blocks of Z-olefinic PNA (Z-OPA) containing the bases adenine and thymine

被引：25

作者：

Cantin, M ^{[1
]}

Schutz, R ^{[1
]}

Leumann, CJ ^{[1
]}

机构：

[1] UNIV BERN, DEPT CHEM & BIOCHEM, CH-3012 BERN, SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(97)00871-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the Boc-protected Z-olefinic peptide nucleic acid analog (Z-OPA) monomers containing the base thymine II and Cbz-adenine 19 is described. Key step in the synthesis of the underlying carbon framework is a Pd(0)-catalyzed coupling of a vinyl iodide, prepared in three steps from 3-butynol, with the Reformatsky reagent derived from ethyl alpha-bromoacetate. (C) 1997 Elsevier Science Ltd.

引用

页码：4211 / 4214

页数：4

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