Imaging {Au0-PAMAM} gold-dendrimer nanocomposites in cells

被引：81

作者：

Bielinska, A ^{[1
]}

Eichman, JD ^{[1
]}

Lee, I ^{[1
]}

Baker, JR ^{[1
]}

Balogh, L ^{[1
]}

机构：

[1] Univ Michigan, Ctr Biol Nanotechnol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2002年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

nanocomposites; dendrimers; imaging; gene transfer; drug delivery; gold/dendrimer composite;

D O I：

10.1023/A:1021692006589

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendritic polymer matrices. They have a great potential in biomedical applications due to their controlled composition, predetermined size, shape and variable surface functionalities. In this work, d = 5-25 nm spherical nanoparticles composed of gold and poly( amidoamine) ( PAMAM) dendrimers have been selected to demonstrate this nanoparticle based concept. {Au(0)(n)-PAMAM} gold dendrimer nanocomposites with a well-defined size were synthesized and imaged by transmission electron microscopy both in vitro and in vivo. DNC have also the potential to be used for imaging and drug delivery vehicles either by utilizing bioactive guests or through the incorporation of radioactive isotopes, such as Au-198.

引用

页码：395 / 403

页数：9

共 34 条

[1] [Anonymous], 1983, J PHYS LETT, DOI DOI 10.1051/IPHYSLET:01983004409035100
[2] [Anonymous], 1984, 1 SPSJ INT POL C SOC
[3] BALOGH L, 1997, POLYM MAT SCI ENG, P118
[4] Formation of silver and gold dendrimer nanocomposites
Balogh, Lajos
Valluzzi, Regina
Laverdure, Kenneth S.
Gido, Samuel P.
Hagnauer, Gary L.
Tomalia, Donald A.
[J]. JOURNAL OF NANOPARTICLE RESEARCH, 1999, 1 (03) : 353 - 368
[5] Molecular modeling of polyamidoamine (PAMAM) Starburst™ dendrimers
Bhalgat, MK
Roberts, JC
[J]. EUROPEAN POLYMER JOURNAL, 2000, 36 (03) : 647 - 651
[6] Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers
Bielinska, A
KukowskaLatallo, JF
Johnson, J
Tomalia, DA
Baker, JR
[J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (11) : 2176 - 2182
[7] DNA complexing with polyamidoamine dendrimers: Implications for transfection
Bielinska, AU
Chen, CL
Johnson, J
Baker, JR
[J]. BIOCONJUGATE CHEMISTRY, 1999, 10 (05) : 843 - 850
[8] The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA
Bielinska, AU
KukowskaLatallo, JF
Baker, JR
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1997, 1353 (02): : 180 - 190
[9] DIFFERENTIAL EXPRESSION OF ALPHA-6 AND ALPHA-2 VERY LATE ANTIGEN INTEGRINS IN THE NORMAL, HYPERPLASTIC, AND NEOPLASTIC PROSTATE - SIMULTANEOUS DEMONSTRATION OF CELL-SURFACE RECEPTORS AND THEIR EXTRACELLULAR LIGANDS
BONKHOFF, H
STEIN, U
REMBERGER, K
[J]. HUMAN PATHOLOGY, 1993, 24 (03) : 243 - 248
[10] Using ethidium bromide to probe the interactions between DNA and dendrimers
Chen, W
Turro, NJ
Tomalia, DA
[J]. LANGMUIR, 2000, 16 (01) : 15 - 19

← 1 2 3 4 →