Inhibitory effects of D-mannose on trypanosomatid lysis induced by Serratia marcescens

被引：24

作者：

Castro, Daniele P. ^{[1
]}

Moraes, Caroline S. ^{[1
]}

Garcia, Eloi S. ^{[1
]}

Azambuja, Patricia ^{[1
]}

机构：

[1] Fiocruz MS, Inst Oswaldo Cruz, Dept Bioquim & Biol Mol, BR-21045900 Rio De Janeiro, Brazil

来源：

EXPERIMENTAL PARASITOLOGY | 2007年 / 115卷 / 02期

关键词：

D-mannose; Trypanosoma cruzi; Trypanosoma rangeli; hemolysis; Serratia marcescens;

D O I：

10.1016/j.exppara.2006.08.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

Studies were carried out on the effects of different carbohydrates on the lysis of Trypanosoma cruzi, Trypanosoma rangeli and erythocytes caused by the bacteria Serratia marcescens variants SM 365 and RPH. High concentrations Of D-mannose were found to protect T cruzi and T rangeli markedly diminishing the lysis caused by S. marcescens. However, this carbohydrate is unable to interfere with the hemolysis induced by SM 365 and RPH variants. These results showed that the trypanolytic effect induced by S. marcescens SM 365 and RPH variants is dependent on D-mannose and distinct from the hemolytic activity, strongly suggesting that bacterial fimbriae are relevant to S. marcescens in lysis of parasites. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：200 / 204

页数：5

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