Endoplasmic Reticulum (ER) Stress-Suppressive Compounds from Scrap Cultivation Beds of the Mushroom Hericium erinaceum

被引：23

作者：

Ueda, Keiko ^{[2
]}

Kodani, Shinya ^{[2
,3
]}

Kubo, Masakazu ^{[4
]}

Masuno, Kazuhiko ^{[5
]}

Sekiya, Atsushi ^{[6
]}

Nagai, Kaoru ^{[1
]}

Kawagishi, Hirokazu ^{[2
,3
]}

机构：

[1] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Epigenet Med, Yamanashi 4093898, Japan

[2] Shizuoka Univ, Grad Sch Sci & Technol, Suruga Ku, Shizuoka 4228529, Japan

[3] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Suruga Ku, Shizuoka 4228529, Japan

[4] Kubo Ind Co Ltd, Nagano 3870003, Japan

[5] Nagano Prefecture Gen Forest Res Ctr, Nagano 3990711, Japan

[6] Forestry & Forest Prod Res Inst, Tsukuba, Ibaraki 3058687, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 08期

关键词：

Hericium erinaceum; mushroom; scrap cultivation bed; structural determination; endoplasmic reticulum stress-suppressive compound; DERIVATIVES; CASPASE-12; APOPTOSIS;

D O I：

10.1271/bbb.90279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Four compounds were isolated from scrap cultivation beds of the mushroom, Hericium erinaceum. Compounds 1-4 were identified as methyl 4-hydroxy-3-(3-methylbutanoyl) benzoate, 2-chloro-1,3-dimethoxy-5-methylbenzene, methyl 4-chloro-3,5-dimethoxybenzoate, and 4-chloro-3,5-dimethoxybenzaldehyde by an interpretation of the NMR and MS data, respectively. This is the first reported isolation of I from a natural source. All the compounds showed protective activity against endoplasmic reticulum stress-dependent cell death.

引用

页码：1908 / 1910

页数：3

共 8 条

[1]

A concise approach to benzoic acid derivatives bearing an α,β-unsaturated ketone substituent:: Synthesis of methyl taboganate [J].

Detsi, A ;

Roussis, V ;

Tsotinis, A ;

Roussakis, C ;

Calogeropoulou, T .

SYNLETT, 2005, (20) :3131-3135

[2]

Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction [J].

Liu, YB ;

Peterson, DA ;

Kimura, H ;

Schubert, D .

JOURNAL OF NEUROCHEMISTRY, 1997, 69 (02) :581-593

[3]

Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway [J].

Nagai, Kaoru ;

Chiba, Akiko ;

Nishino, Toru ;

Kubota, Takeo ;

Kawagishi, Hirokazu .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2006, 17 (08) :525-530

[4]

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β [J].

Nakagawa, T ;

Zhu, H ;

Morishima, N ;

Li, E ;

Xu, J ;

Yankner, BA ;

Yuan, JY .

NATURE, 2000, 403 (6765) :98-103

[5]

Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis [J].

Nakagawa, T ;

Yuan, JY .

JOURNAL OF CELL BIOLOGY, 2000, 150 (04) :887-894

[6]

ANTIMICROBIAL CHLORINATED ORCINOL DERIVATIVES FROM MYCELIA OF HERICIUM-ERINACEUM [J].

OKAMOTO, K ;

SHIMADA, A ;

SHIRAI, R ;

SAKAMOTO, H ;

YOSHIDA, S ;

OJIMA, F ;

ISHIGURO, Y ;

SAKAI, T ;

KAWAGISHI, H .

PHYTOCHEMISTRY, 1993, 34 (05) :1445-1446

[7]

QIAN F G, 1990, Yaoxue Xuebao, V25, P522

[8]

An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum [J].

Ueda, Keiko ;

Tsujimori, Megumi ;

Kodani, Shinya ;

Chiba, Akiko ;

Kubo, Masakazu ;

Masuno, Kazuhiko ;

Sekiya, Atsushi ;

Nagai, Kaoru ;

Kawagishi, Hirokazu .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (21) :9467-9470

← 1 →