Family-based association tests for quantitative traits using pooled DNA

被引：6

作者：

Bader, JS

Sham, P

机构：

[1] CuraGen Corp, New Haven, CT 06511 USA

[2] Kings Coll London, Inst Psychiat, Dept Med Psychol, London, England

[3] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychait Res Ctr, London, England

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2002年 / 10卷 / 12期

关键词：

association; linkage; quantitative trait locus (QTL); single-nucleoticle polymorphism (SNP); DNA pooling; genotyping;

D O I：

10.1038/sj.ejhg.5200893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.

引用

页码：870 / 878

页数：9

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