Molecular probes for the in vivo imaging of cancer

被引：52

作者：

Alford, Raphael ^{[1
,2
]}

Ogawa, Mikako ^{[1
]}

Choyke, Peter L. ^{[1
]}

Kobayashi, Hisataka ^{[1
]}

机构：

[1] NCI, Mol Imaging Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] Case Western Reserve Sch Med, Cleveland, OH USA

来源：

MOLECULAR BIOSYSTEMS | 2009年 / 5卷 / 11期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; FLUORESCENCE LIFETIME SPECTROSCOPY; MAGNETIC-RESONANCE; FDG-PET; BREAST-CANCER; F-18-FLT PET; RESPONSE ASSESSMENT; TUMOR-CELLS; LYMPH-NODES; PHASE-I;

D O I：

10.1039/b911307j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advancements in medical imaging have brought about unprecedented changes in the in vivo assessment of cancer. Positron emission tomography, single photon emission computed tomography, optical imaging, and magnetic resonance imaging are the primary tools being developed for oncologic imaging. These techniques may still be in their infancy, as recently developed chemical molecular probes for each modality have improved in vivo characterization of physiologic and molecular characteristics. Herein, we discuss advances in these imaging techniques, and focus on the major design strategies with which molecular probes are being developed.

引用

页码：1279 / 1291

页数：13

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