Dexamethasone-methotrexate:: An efficient chemical inducer of protein dimerization in vivo

被引：79

作者：

Lin, HN

Abida, WM

Sauer, RT

Cornish, VW ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 17期

关键词：

D O I：

10.1021/ja9941532

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：4247 / 4248

页数：2

共 26 条

[1]

ADAMS A, 1998, METHODS YEAST GENETI, P123

[2] A versatile synthetic dimerizer for the regulation of protein-protein interactions [J].

Amara, JF ;

Clackson, T ;

Rivera, VM ;

Guo, T ;

Keenan, T ;

Natesan, S ;

Pollock, R ;

Yang, W ;

Courage, NL ;

Holt, DA ;

Gilman, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10618-10623

[3] Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins [J].

Belshaw, PJ ;

Ho, SN ;

Crabtree, GR ;

Schreiber, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) :4604-4607

[4] INSIGHTS INTO ENZYME FUNCTION FROM STUDIES ON MUTANTS OF DIHYDROFOLATE-REDUCTASE [J].

BENKOVIC, SJ ;

FIERKE, CA ;

NAYLOR, AM .

SCIENCE, 1988, 239 (4844) :1105-1110

[5]

BOLIN J, 1992, J BIOL CHEM, V257, P13663

[6] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].

BROWN, EJ ;

ALBERS, MW ;

SHIN, TB ;

ICHIKAWA, K ;

KEITH, CT ;

LANE, WS ;

SCHREIBER, SL .

NATURE, 1994, 369 (6483) :756-758

[7]

CHAKRABORTI PK, 1991, J BIOL CHEM, V266, P22075

[8] Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity [J].

Clackson, T ;

Yang, W ;

Rozamus, LW ;

Hatada, M ;

Amara, JF ;

Rollins, CT ;

Stevenson, LF ;

Magari, SR ;

Wood, SA ;

Courage, NL ;

Lu, XD ;

Cerasoli, F ;

Gilman, M ;

Holt, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) :10437-10442

[9] Single-step synthesis of cell-permeable protein dimerizers that activate signal transduction and gene expression [J].

Diver, ST ;

Schreiber, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (22) :5106-5109

[10]

ESPENSHADE P, 1997, THESIS MIT

← 1 2 3 →