Fosmidomycin for malaria

被引：184

作者：

Missinou, MA

Borrmann, S

Schindler, A

Issifou, S

Adegnika, AA

Matsiegui, PB

Binder, R

Lell, B

Wiesner, J

Baranek, T

Jomaa, H

Kremsner, PG ^{[1
]}

机构：

[1] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon

[2] Univ Tubingen, Inst Trop Med, Dept Parasitol, D-72074 Tubingen, Germany

[3] Jomaa Pharmaka GmbH, Giessen, Germany

来源：

LANCET | 2002年 / 360卷 / 9349期

关键词：

D O I：

10.1016/S0140-6736(02)11860-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Safe and effective antimalarial drugs with new methods of action are urgently needed. Fosmidomycin inhibits the synthesis of isoprenoid by Plasmodium falciparum, and suppresses the growth of multidrug-resistant strains in vitro. Our aim was to assess the efficacy and tolerability of fosmidomycin in adults with malaria in Gabon. We administered the drug for 5, 4, or 3 days (1-2 g every 8 h), in nine, eight, and ten evaluable patients, respectively. All treatment regimens were well tolerated. Cure rates by day 14 were 89% (eight of nine), 88% (seven of eight), and 60% (six of ten), for treatment durations of 5, 4, and 3 days, respectively. These data suggest that fosmidomycin is a safe and effective treatment for uncomplicated malaria if given for 4 days or more.

引用

页码：1941 / 1942

页数：2

共 5 条

[1] Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs [J].

Jomaa, H ;

Wiesner, J ;

Sanderbrand, S ;

Altincicek, B ;

Weidemeyer, C ;

Hintz, M ;

Türbachova, I ;

Eberl, M ;

Zeidler, J ;

Lichtenthaler, HK ;

Soldati, D ;

Beck, E .

SCIENCE, 1999, 285 (5433) :1573-1576

[2]

KUEMMERLE HP, 1985, INT J CLIN PHARM TH, V23, P521

[3]

Mordmuller B, 1998, WIEN KLIN WOCHENSCHR, V110, P321

[4] PHARMACOKINETICS OF FOSMIDOMYCIN, A NEW PHOSPHONIC ACID ANTIBIOTIC [J].

MURAKAWA, T ;

SAKAMOTO, H ;

FUKADA, S ;

KONISHI, T ;

NISHIDA, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 21 (02) :224-230

[5]

WINKLER S, 1994, TROP MED PARASITOL, V45, P214

← 1 →