Atomic force microscopy study of erythrocyte shape and membrane structure after treatment with a dihydropyridinic drug

被引：11

作者：

Girasole, M

Cricenti, A

Generosi, R

Congiu-Castellano, A

Boffi, F

Arcovito, A

Boumis, G

Amiconi, G

机构：

[1] CNR, Ist Struttura Mat, I-00133 Rome, Italy

[2] Univ La Sapienza, Dipartimento Fis, I-00185 Rome, Italy

[3] INFM Roma, I-00185 Rome, Italy

[4] Univ La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy

[5] CNR, Ctr Studio Biol Mol, I-00185 Rome, Italy

来源：

APPLIED PHYSICS LETTERS | 2000年 / 76卷 / 24期

关键词：

D O I：

10.1063/1.126736

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The overall shape and membrane surface of human erythrocytes (RBCs) in the presence of nifedipine (a dihydropyridinic drug used in the clinical treatment of hypertension and angina pectoris) were imaged by contact-mode atomic force microscopy. Nifedipine induces in RBCs relevant morphological changes the extent of which increases as a function of drug concentration and incubation time. The modifications have been interpreted as mainly due to insertion of nifedipine into the outer layer of the RBC membrane. The potential effect of nifedipine as a hemoglobin denaturant has been ruled out by x-ray absorption near-edge structure and optical spectroscopies. (C) 2000 American Institute of Physics. [S0003-6951(00)01024-X].

引用

页码：3650 / 3652

页数：3

共 17 条

[1]

Acin P, 1997, EUR J HAEMATOL, V59, P190

[2] BINDING OF ORGANIC IONS BY PROTEINS .2. EFFECT OF 1-BENZYL-3-INDAZOLEOXYACETATE AT LOW CONCENTRATION ON THE OXYGEN-AFFINITY OF HUMAN-HEMOGLOBIN [J].