Tissue engineering: Orthopedic applications

被引:572
作者
Laurencin, CT [1 ]
Ambrosio, AMA [1 ]
Borden, MD [1 ]
Cooper, JA [1 ]
机构
[1] Drexel Univ, Dept Chem Engn, Ctr Adv Biomat & Tissue Engn, Philadelphia, PA 19104 USA
关键词
bone; ligament; cartilage; scaffold; biomaterials;
D O I
10.1146/annurev.bioeng.1.1.19
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Because of an aging population and increased occurrence of sports-related injuries, musculoskeletal disorders have become one of the major health concerns in the United States. Current treatments, although fairly successful, do not provide the optimum therapy. These treatments typically rely on donor tissues obtained either from the patient or from another source. The former raises the issue of supply, whereas the latter poses the risk of rejection and disease transfer. This has prompted orthopedic surgeons and scientists to look for viable alternatives. In recent years, tissue engineering has gained increasing support as a method to treat orthopedic disorders. Because it uses principles of engineering, biology, and chemistry, tissue engineering may provide a more effective approach to the treatment of musculoskeletal disorders than traditional methods. This chapter presents a review of current methods and new tissue-engineering techniques for the treatment of disorders affecting bone, ligament, and cartilage.
引用
收藏
页码:19 / 46
页数:28
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