Intravenous lipid infusion and total plasma fatty acids positively modulate plasma acylated ghrelin, in vivo

被引：7

作者：

Barazzoni, R. ^{[1
]}

Cappellari, G. Gortan ^{[1
]}

Semolic, A. ^{[1
]}

Ius, M. ^{[1
]}

Dore, F. ^{[2
]}

Giacca, M. ^{[3
]}

Zanetti, M. ^{[1
]}

Vinci, P. ^{[1
]}

Guarnieri, G. ^{[1
]}

机构：

[1] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[2] Azienda Osped Univ Osped Riuniti, Dept Nucl Med, Trieste, Italy

[3] Int Ctr Genet Engn & Biotechnol, Mol Med Lab, Trieste, Italy

来源：

CLINICAL NUTRITION | 2017年 / 36卷 / 03期

关键词：

Ghrelin; Free fatty acids; Acylation; INSULIN-RESISTANCE; ENERGY-BALANCE; HUMANS; TRANSFERASE; DYSFUNCTION; OVERWEIGHT; INHIBITOR; GLUCOSE; WEIGHT; WOMEN;

D O I：

10.1016/j.clnu.2016.05.017

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background & aims: Ghrelin is a gastric orexigenic hormone whose activating acylation plays a relevant role in the regulation of energy balance. Nutritional modulators of ghrelin acylation and plasma acylated ghrelin (AG) concentration remain however largely undefined. We aimed at investigating whether circulating free fatty acids (FFA) contribute to regulate plasma AG and its ratio (AG/TG) to total hormone (TG). Methods: Plasma FFA, TG, AG and AG/TG were measured in a primary outpatient care setting in a community-based population cohort of 850 individuals (age 54 10 years, M/F: 408/442) from the North-East Italy MoMa study. 150-min intravenous lipid infusions in rodents (10% lipids, 600 mu l/h) were used to investigate the potential causal role of FFA in the regulation of plasma ghrelin profile. Results: Plasma FFA were associated positively with AG and AG/TG while negatively with TG (P < 0.01). Associations between FFA, AG and AG/TG remained statistically significant (P < 0.02) in multiple regression analysis including HOMA insulin resistance and metabolic confounders, and both AG and AG/TG but not TG increased through plasma FFA quartiles (P < 0.01). Consistent with these findings, intravenous lipid infusion with plasma FFA elevation caused elevations of AG and AG/TG (P < 0.05) with no TG modifications. Conclusions: The current findings demonstrate a novel role for circulating FFA availability to up-regulate plasma AG, which could involve FFA-induced stimulation of ghrelin acylation. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：775 / 781

页数：7

共 22 条

[1]

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction [J].