Pathophysiology and Management of the Burn Scar

被引：51

作者：

Ladak, Adil ^{[1
]}

Tredget, Edward E. ^{[1
]}

机构：

[1] Univ Alberta, Dept Surg, Div Plast & Reconstruct Surg & Crit Care, Edmonton, AB T6G 2B7, Canada

来源：

CLINICS IN PLASTIC SURGERY | 2009年 / 36卷 / 04期

基金：

加拿大健康研究院;

关键词：

Burns; Hypertrophic scar; Treatment; Outcome; Fibroproliferative disorder; GROWTH-FACTOR-BETA; POSTBURN HYPERTROPHIC SCAR; PERIPHERAL-BLOOD FIBROCYTES; HUMAN DERMAL FIBROBLASTS; T-HELPER-CELL; TGF-BETA; MESSENGER-RNA; FACTOR-I; CIRCULATING FIBROCYTES; EXTRACELLULAR-MATRIX;

D O I：

10.1016/j.cps.2009.05.014

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Fibroproliferative disorders (FPDs) are common and serious disorders. Hypertrophic scar (HSc) and keloids represent the dermal equivalents of FPD and impose lower mortality but great morbidity. This article reviews current knowledge in the pathophysiology and molecular and cellular characteristics of postburn HSc. Additionally, current treatment modalities and future treatment options based on advancements in the understanding of the pathophysiology of HSc are discussed.

引用

收藏

页码：661 / +

页数：15

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