Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants

被引：786

作者：

Degenhardt, Joerg ^{[1
]}

Koellner, Tobias G. ^{[1
]}

Gershenzon, Jonathan ^{[2
]}

机构：

[1] Univ Halle Wittenberg, Inst Pharm, D-06120 Halle, Germany

[2] Max Planck Inst Chem Ecol, D-07745 Jena, Germany

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 15-16期

关键词：

Monoterpene synthase; Sesquiterpene synthase; Terpene synthase reaction mechanism; Site-directed mutagenesis; Terpene synthase structure; Structure-function correlation; ARTEMISIA-ANNUA L; SAGE SALVIA-OFFICINALIS; D-LIMONENE SYNTHASE; CITRUS-UNSHIU MARC; MENTHA X PIPERITA; FIR ABIES-GRANDIS; TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE; (+)-BORNYL DIPHOSPHATE SYNTHASE; INDUCED VOLATILE FORMATION; SITE-DIRECTED MUTAGENESIS;

D O I：

10.1016/j.phytochem.2009.07.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The multitude of terpene carbon skeletons in plants is formed by enzymes known as terpene synthases. This review covers the monoterpene and sesquiterpene synthases presenting an up-to-date list of enzymes reported and evidence for their ability to form multiple products. The reaction mechanisms of these enzyme classes are described, and information on how terpene synthase proteins mediate catalysis is summarized. Correlations between specific amino acid motifs and terpene synthase function are described, including an analysis of the relationships between active site sequence and cyclization type and a discussion of whether specific protein features might facilitate multiple product formation. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1621 / 1637

页数：17

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