Ten genes for inherited breast cancer

被引：334

作者：

Walsh, Tom

King, Mary-Claire ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

CANCER CELL | 2007年 / 11卷 / 02期

关键词：

D O I：

10.1016/j.ccr.2007.01.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inherited breast cancer is associated with germline mutations in ten different genes in pathways critical to genomic integrity. BRCA1 and BRCA2 mutations confer very high risks of breast and ovarian cancer. p53 and PTEN mutations lead to very high breast cancer risks associated with rare cancer syndromes. Mutations in CHEK2, ATM, NBS1, RAD50, BRIP1, and PALB2 are associated with doubling of breast cancer risks. In addition, biallelic mutations in BRCA2, BRIP1, and PALB2 cause Fanconi anemia. The convergence of these genes in a shared role reveals underlying biology of these illnesses and suggests still other breast cancer genes.

引用

页码：103 / 105

页数：3

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