The Prominent Role of Neutrophils during the Initial Phase of Infection by Leishmania Parasites

被引:61
作者
Charmoy, Melanie [1 ]
Auderset, Floriane [1 ]
Allenbach, Cindy [1 ]
Tacchini-Cottier, Fabienne [1 ]
机构
[1] Univ Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, Switzerland
来源
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年
基金
瑞士国家科学基金会;
关键词
TNF RECEPTOR P55; MAJOR INFECTION; CUTANEOUS LEISHMANIASIS; MICE LACKING; IN-VIVO; RESISTANT; CELLS; GRANULOCYTES; APOPTOSIS; LESIONS;
D O I
10.1155/2010/719361
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.
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页数:8
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