The Prominent Role of Neutrophils during the Initial Phase of Infection by Leishmania Parasites
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作者:
Charmoy, Melanie
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Univ Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, SwitzerlandUniv Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, Switzerland
Charmoy, Melanie
[1
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Auderset, Floriane
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Univ Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, SwitzerlandUniv Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, Switzerland
Auderset, Floriane
[1
]
Allenbach, Cindy
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Univ Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, SwitzerlandUniv Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, Switzerland
Allenbach, Cindy
[1
]
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Tacchini-Cottier, Fabienne
[1
]
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[1] Univ Lausanne, Dept Biochem, WHO Immunol Res & Training Ctr, CH-1066 Epalinges, Switzerland
Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.
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Univ Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, SwitzerlandUniv Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, Switzerland
Allenbach, Cindy
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Launois, Pascal
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Univ Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, SwitzerlandUniv Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, Switzerland
机构:
Rhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Daley, Jean M.
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Thomay, Alan A.
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Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Thomay, Alan A.
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Connolly, Michael D.
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Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Connolly, Michael D.
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Reichner, Jonathan S.
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Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Reichner, Jonathan S.
;
Albina, Jorge E.
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Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
机构:
Univ Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, SwitzerlandUniv Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, Switzerland
Allenbach, Cindy
;
Launois, Pascal
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Univ Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, SwitzerlandUniv Lausanne, WHO Immunol Res & Training Ctr, Dept Biochem, CH-1066 Epalinges, Switzerland
机构:
Rhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Daley, Jean M.
;
Thomay, Alan A.
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Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Thomay, Alan A.
;
Connolly, Michael D.
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机构:
Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Connolly, Michael D.
;
Reichner, Jonathan S.
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h-index: 0
机构:
Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA
Reichner, Jonathan S.
;
Albina, Jorge E.
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Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Surg, Providence, RI USARhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA