Nuclear transport and transcription

被引：88

作者：

Komeili, A ^{[1
]}

O'Shea, EK ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(00)00100-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation. In addition, nuclear transport prays a crucial role in regulating the activity of many transcription factors.

引用

页码：355 / 360

页数：6

共 24 条

[1]

BARBARIC S, 1992, NUCLEIC ACIDS RES, V5, P2689

[2] CRM1 is an export receptor for leucine-rich nuclear export signals [J].

Fornerod, M ;

Ohno, M ;

Yoshida, M ;

Mattaj, IW .

CELL, 1997, 90 (06) :1051-1060

[3] Transcriptional regulation - Modification by nuclear export? [J].

Hogan, PG ;

Rao, A .

NATURE, 1999, 398 (6724) :200-201

[4] Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Psel/Kapl21 [J].

Kaffman, A ;

Rank, NM ;

O'Shea, EK .

GENES & DEVELOPMENT, 1998, 12 (17) :2673-2683

[5] The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus [J].

Kaffman, A ;

Rank, NM ;

O'Neill, EM ;

Huang, LS ;

O'Shea, EK .

NATURE, 1998, 396 (6710) :482-486

[6] PHOSPHORYLATION OF THE TRANSCRIPTION FACTOR-PHO4 BY A CYCLIN-CDK COMPLEX, PHO80-PHO85 [J].

KAFFMAN, A ;

HERSKOWITZ, I ;

TJIAN, R ;

OSHEA, EK .

SCIENCE, 1994, 263 (5150) :1153-1156

[7] Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation [J].

Khokhlatchev, AV ;

Canagarajah, B ;

Wilsbacher, J ;

Robinson, M ;

Atkinson, M ;

Goldsmith, E ;

Cobb, MH .

CELL, 1998, 93 (04) :605-615

[8] Roles of phosphorylation sites in regulating activity of the transcription factor Pho4 [J].

Komeili, A ;

O'Shea, EK .

SCIENCE, 1999, 284 (5416) :977-980

[9] SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53 [J].

LEE, WT ;

HARVEY, TS ;

YIN, Y ;

YAU, P ;

LITCHFIELD, D ;

ARROWSMITH, CH .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (12) :877-890

[10] The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited [J].

Middeler, G ;

Zerf, K ;

Jenovai, S ;

Thulig, A ;

TschodrichRotter, M ;

Kubitscheck, U ;

Peters, R .

ONCOGENE, 1997, 14 (12) :1407-1417

← 1 2 3 →