Transcript elongation on a nucleoprotein template

被引：52

作者：

Hartzog, GA ^{[1
]}

Speer, JL ^{[1
]}

Lindstrom, DL ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2002年 / 1577卷 / 02期

基金：

美国国家卫生研究院;

关键词：

transcription elongation; chromatin; RNA polymerase II; nucleosome; FACT; DSIF;

D O I：

10.1016/S0167-4781(02)00458-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and historic modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：276 / 286

页数：11

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