Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

被引：305

作者：

Wagner, KR

McPherron, AC

Winik, N

Lee, SJ

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 06期

关键词：

D O I：

10.1002/ana.10385

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Myostatin, a transforming growth factor-B family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.

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页码：832 / 836

页数：5

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