Novel therapies for an old virus: treatment of RSV infections in the 21st Century

被引：7

作者：

Luesebrink, Jessica ^{[2
]}

Schildgen, Verena ^{[2
]}

Schildgen, Oliver ^{[1
]}

机构：

[1] Kliniken Stadt Koln, Inst Pathol, D-51109 Cologne, Germany

[2] Univ Bonn, Inst Virol, Med Ctr, D-53105 Bonn, Germany

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2009年 / 7卷 / 09期

关键词：

children; clinical trials; drugs; elderly; high-risk patients; RSV; treatment; RESPIRATORY SYNCYTIAL VIRUS; ANTIVIRAL ACTIVITY; COTTON RATS; IN-VITRO; ANTISENSE OLIGOMERS; COMPLICATED COURSE; FUSION INHIBITOR; VACCINE; SAFETY; IMMUNOGENICITY;

D O I：

10.1586/ERI.09.90

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Respiratory syncytial virus (RSV) is a pathogen whose existence has been known for decades, causing mild-to-severe upper and lower respiratory tract infections that bear the risk of subsequent asthma and can even lead to a fatal outcome. RSV infects all groups of patients and is a major cause of hospitalization in children and in the elderly. This review briefly summarizes the current status of RSV drug development and clinical trials for drugs available for the treatment of RSV infections.

引用

页码：1125 / 1129

页数：5

共 53 条

[1]

Revised indications for the use of Palivizumab and Respiratory Syncytial Virus Immune Globulin Intravenous for the prevention of respiratory syncytial virus infections [J].

Abramson, JS ;

Baker, CJ ;

Baltimore, RS ;

Bocchini, JA ;

Long, SS ;

McMillan, JA ;

Meissner, HC ;

Powell, KR ;

Prober, CG ;

Rennels, MB ;

Saari, TN ;

Weiner, LB ;

Blackmon, L ;

Batton, DG ;

Bell, EF ;

Denson, SE ;

Engle, WA ;

Kanto, WP ;

Martin, GI ;

Stark, AR .

PEDIATRICS, 2003, 112 (06) :1447-1452

[2]

Inhibition of respiratory viruses by nasally administered siRNA [J].

Bitko, V ;

Musiyenko, A ;

Shulyayeva, O ;

Barik, S .

NATURE MEDICINE, 2005, 11 (01) :50-55

[3]

Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121) [J].

Bonfanti, Jean-Francois ;

Meyer, Christophe ;

Doublet, Frederic ;

Fortin, Jerome ;

Muller, Philippe ;

Queguiner, Laurence ;

Gevers, Tom ;

Janssens, Peggy ;

Szel, Heidi ;

Willebrords, Rudy ;

Timmerman, Philip ;

Wuyts, Koen ;

van Remoortere, Pieter ;

Janssens, Frans ;

Wigerinck, Piet ;

Andries, Koen .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (04) :875-896

[4]

Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion [J].

Cianci, C ;

Langley, DR ;

Dischino, DD ;

Sun, YX ;

Yu, KL ;

Stanley, A ;

Roach, J ;

Li, ZF ;

Dalterio, R ;

Colonno, R ;

Meanwell, NA ;

Krystal, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (42) :15046-15051

[5]

Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection [J].

Cianci, C ;

Genovesi, EV ;

Lamb, L ;

Medina, I ;

Yang, Z ;

Zadjura, L ;

Yang, H ;

D'Arienzo, C ;

Sin, N ;

Yu, KL ;

Combrink, K ;

Li, ZF ;

Colonno, R ;

Meanwell, N ;

Clark, J ;

Krystal, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (07) :2448-2454

[6]

Orally active fusion inhibitor of respiratory syncytial virus [J].

Cianci, C ;

Yu, KL ;

Combrink, K ;

Sin, N ;

Pearce, B ;

Wang, A ;

Civiello, R ;

Voss, S ;

Luo, GX ;

Kadow, K ;

Genovesi, EV ;

Venables, B ;

Gulgeze, H ;

Trehan, A ;

James, J ;

Lamb, L ;

Medina, I ;

Roach, J ;

Yang, Z ;

Zadjura, L ;

Colonno, R ;

Clark, J ;

Meanwell, N ;

Krystal, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (02) :413-422

[7]

DE CE, 1991, ANTIMICROB AGENTS CH, V35, P679

[8]

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV) [J].

DeVincenzo, John ;

Cehelsky, Jeffrey E. ;

Alvarez, Rene ;

Elbashir, Ayda ;

Elbashir, Sayda ;

Harborth, Jens ;

Toudjarska, Iva ;

Nechev, Lubornir ;

Murugaiah, Veeravagu ;

Van Vliet, Andre ;

Vaishnaw, Akshay K. ;

Meyers, Rachel .

ANTIVIRAL RESEARCH, 2008, 77 (03) :225-231

[9]

Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms [J].

Douglas, JL ;

Panis, ML ;

Ho, E ;

Lin, KY ;

Krawczyk, SH ;

Grant, DM ;

Cai, R ;

Swaminathan, S ;

Chen, XW ;

Cihlar, T .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (06) :2460-2466

[10]

Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP 2) in ambulatory adults over age 60 [J].

Falsey, AR ;

Walsh, EE .

VACCINE, 1996, 14 (13) :1214-1218

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