The role of platelets CD40 ligand (CD154) in acute coronary syndromes

被引：18

作者：

Abu El-Makrem, Mona A. ^{[2
]}

Mahmoud, Yehia Z. ^{[2
]}

Sayed, Douaa ^{[1
]}

Nassef, Noussa M. ^{[1
]}

Abd El-Kader, Samir S. ^{[3
]}

Zakhary, Madiha ^{[4
]}

Ghazaly, Taghreed ^{[1
]}

Matta, Ragaa ^{[2
]}

机构：

[1] Assiut Univ, S Egypt Canc Inst, Dept Clin Pathol, Flow Cytometry Lab, Assiut, Egypt

[2] Menia Univ, Dept Internal Med, Fac Med, El Minia, Egypt

[3] Assiut Univ, Coronary Dept, Fac Med, Assiut, Egypt

[4] Assiut Univ, Dept Biochem, Fac Med, Assiut, Egypt

来源：

THROMBOSIS RESEARCH | 2009年 / 124卷 / 06期

关键词：

Acute Coronary Syndrome; CD154; Flow Cytometry; Platelets; ARTERY-DISEASE; UP-REGULATION; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; IN-VIVO; ACTIVATION; HYPERTENSION; EXPRESSION; PLASMA; SERUM;

D O I：

10.1016/j.thromres.2009.06.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Despite of the proof of the biological function of CD154 on platelets, there has been little information about its role either in patients with stable angina or in those with acute coronary syndrome (ACS). Objective: This study aimed to investigate the expression of CD154 on platelets and its role in ACS. Methods: The study included 50 patients with ACS (24 patients with acute myocardial infarction (AMI) and 26 patients with unstable angina (UA)), 20 patients with stable angina (SA) and 18 healthy volunteers. CD154 and CD62 expression on platelets were analyzed by flow cytometry. Their relations to the clinical and laboratory data were assessed in the studied group. Results: Patients with AMI and UA had higher levels of platelets CD154 and CD62 as compared to those with SA and among patients with AMI, UA and SA versus healthy volunteers. Platelets CD154 showed significant positive correlations with the studied pro-inflammatory markers (Ox-LDL CRP and fibrinogen), segmental wall motion score and the studied risk factors. There were significant negative correlations between platelet CD154 and serum nitric oxide among patients. Conclusions: CD154 may be used as a marker of thrombo-embolic events. Nitric oxide may have an anti-atherogenic effect. There is an association between platelet activation and severity of coronary artery disease among patients with ACS. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：683 / 688

页数：6

共 40 条

[1] Metabolic syndrome - a new world-wide definition. A consensus statement from the international diabetes federation [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

DIABETIC MEDICINE, 2006, 23 (05) :469-480

[2]

ANTMAN EM, 1997, HEART DIS, P1946

[3]

CHUNG BH, 1980, J LIPID RES, V21, P284

[4] PREDICTION OF CREATININE CLEARANCE FROM SERUM CREATININE [J].

COCKCROFT, DW ;

GAULT, MH .

NEPHRON, 1976, 16 (01) :31-41

[5] Platelet activation in obese women -: Role of inflammation and oxidant stress [J].

Davì, G ;

Guagnano, MT ;

Ciabattoni, G ;

Basili, S ;

Falco, A ;

Marinopiccoli, M ;

Nutini, M ;

Sensi, S ;

Patrono, C .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (16) :2008-2014

[6] CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivo [J].

Davis, B ;

Zou, MH .

CIRCULATION, 2005, 112 (14) :2184-2192

[7]

Fuster V., 2008, CECIL MED, V23rd, P472

[8] Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia [J].

Garlichs, CD ;

John, S ;

Schmeisser, A ;

Eskafi, S ;

Stumpf, C ;

Karl, M ;

Goppelt-Struebe, M ;

Schmieder, R ;

Daniel, WG .

CIRCULATION, 2001, 104 (20) :2395-2400

[9] Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets [J].

Garlichs, CD ;

Eskafi, S ;

Raaz, D ;

Schmidt, A ;

Ludwig, J ;

Herrmann, M ;

Klinghammer, L ;

Daniel, WG ;

Schmeisser, A .

HEART, 2001, 86 (06) :649-655

[10] The stratification of platelet reactivity and activation in patients with stable coronary artery disease on aspirin therapy [J].

Gurbel, PA ;

Bliden, KP .

THROMBOSIS RESEARCH, 2003, 112 (1-2) :9-12

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