TRP channels: new targets for visceral pain

被引:70
作者
Blackshaw, L. A. [1 ,2 ,3 ]
Brierley, S. M. [1 ,2 ]
Hughes, P. A. [1 ,2 ]
机构
[1] Royal Adelaide Hosp, Hanson Inst, Dept Gastroenterol & Hepatol, Nerve Gut Res Lab, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Sch Mol & Biomed Sci, Discipline Physiol, Adelaide, SA, Australia
[3] Univ Adelaide, Discipline Med, Adelaide, SA, Australia
基金
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词
IRRITABLE-BOWEL-SYNDROME; CAPSAICIN RECEPTOR TRPV1; VAGAL AFFERENT NEURONS; GUINEA-PIG ESOPHAGUS; PELVIC COLONIC AFFERENTS; TRANSIENT RECEPTOR; VANILLOID RECEPTOR; GASTROINTESTINAL-TRACT; SENSORY NEURONS; ION CHANNELS;
D O I
10.1136/gut.2009.179523
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
[No abstract available]
引用
收藏
页码:126 / 135
页数:10
相关论文
共 112 条
[1]
A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model [J].
Adam, B ;
Liebregts, T ;
Best, J ;
Bechmann, L ;
Lackner, C ;
Neumann, J ;
Koehler, S ;
Holtmann, G .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2006, 41 (02) :155-160
[2]
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain [J].
Akbar, A. ;
Yiangou, Y. ;
Facer, P. ;
Walters, J. R. F. ;
Anand, P. ;
Ghosh, S. .
GUT, 2008, 57 (07) :923-929
[3]
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization [J].
Akopian, Armen N. ;
Ruparel, Nikita B. ;
Jeske, Nathaniel A. ;
Hargreaves, Kenneth M. .
JOURNAL OF PHYSIOLOGY-LONDON, 2007, 583 (01) :175-193
[4]
Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier [J].
Alvarez, Diego F. ;
King, Judy A. ;
Weber, David ;
Addison, Emile ;
Liedtke, Wolfgang ;
Townsley, Mary I. .
CIRCULATION RESEARCH, 2006, 99 (09) :988-995
[5]
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia [J].
Amadesi, S ;
Nie, JJ ;
Vergnolle, N ;
Cottrell, GS ;
Grady, EF ;
Trevisani, M ;
Manni, C ;
Geppetti, P ;
McRoberts, JA ;
Ennes, H ;
Davis, B ;
Mayer, EA ;
Bunnett, NW .
JOURNAL OF NEUROSCIENCE, 2004, 24 (18) :4300-4312
[6]
Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction [J].
Andrews, PLR ;
Sanger, GJ .
CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (06) :650-656
[7]
Mechanisms of hypersensitivity in IBS and functional disorders [J].
Azpiroz, F. ;
Bouin, M. ;
Camilleri, M. ;
Mayer, E. A. ;
Poitras, P. ;
Serra, J. ;
Spiller, R. C. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2007, 19 :62-88
[8]
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin [J].
Bandell, M ;
Story, GM ;
Hwang, SW ;
Viswanath, V ;
Eid, SR ;
Petrus, MJ ;
Earley, TJ ;
Patapoutian, A .
NEURON, 2004, 41 (06) :849-857
[9]
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome [J].
Barbara, G ;
Stanghellini, V ;
De Giorgio, R ;
Cremon, C ;
Cottrell, GS ;
Santini, D ;
Pasquinelli, G ;
Morselli-Labate, AM ;
Grady, EF ;
Bunnett, NW ;
Collins, SM ;
Corinalidesi, R .
GASTROENTEROLOGY, 2004, 126 (03) :693-702
[10]
Pungent products from garlic activate the sensory ion channel TRPA1 [J].
Bautista, DM ;
Movahed, P ;
Hinman, A ;
Axelsson, HE ;
Sterner, O ;
Högestätt, ED ;
Julius, D ;
Jordt, SE ;
Zygmunt, PM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (34) :12248-12252